Blog

ENDOR™ Arthritis Gel – FAQ

1- What is ENDOR Arthritis Gel for?

ENDOR Arthritis Gel has been developed to help inflammatory muscular stiffness, aches and pains and also to reduce joint inflammation, provide lubrication and help with joint movement.

2- Where can I apply it?

ENDOR Arthritis Gel is a topical product. You will need to apply it to joints and muscular aches and pains. You should rub the gel into the skin to help absorption into the skin. If necessary, you may also moisten your hand and rub over the treated area to improve absorption into the skin.

3- How often should I use ENDOR Arthritis Gel?

You should use the ENDOR Arthritis Gel when you have pain. The frequency of use will be reduced to once per day or when required.

4- Can anyone use ENDOR Arthritis Gel?

ENDOR Arthritis Gel is safe to use on anyone from 12 years of age. It is not recommended to be used on children below 12 years.

Gel - 31:10:17.jpg

5- How much is it?

Please visit our website www.gnpau.com for current prices and any offers.

5- Where can I buy ENDOR Arthritis Gel?

We sell through some chemists and pharmacies but our preference is for you to purchase direct from us. We also recommend that you contact us first and ask for relevant information regarding your condition and whether our products are appropriate for your condition.

6- How does ENDOR Arthritis Gel work?

ENDOR Arthritis Gel contains the precursors to the ENDOR active compound for the inhibition and reduction of inflammatory immune response. It also contains a number of ingredients to assist with joint lubrication and mobility.

7- Can I use ENDOR Arthritis Gel whilst using steroidal based products?

No you cannot. This is because ENDOR Products contain the precursors to an active compound, that the person’s own immune cells can make. If you are using Steroidal products or any other product that dampens your immune response, this will stop the conversion of these precursors into the active compound.

6.jpg

8- Can ENDOR Arthritis Gel help with the pain?

ENDOR Arthritis Gel reduces the inflammation in the joints and aching muscles. Once the inflammation has been reduced or stopped, then the natural healing process will take over and the pain is reduced or removed.

9- How long does it take to start showing some results?

Upon using the ENDOR Arthritis Gel, you will begin seeing some relief. The length of time that the pain relief works, very much depends on your condition and the severity of your condition, however, with continued use, the length of time will increase and in most instances, only once or twice daily applications should suffice.

10- What are the ingredients used for ENDOR Arthritis Gel?

You can find the ingredients for all of our products on our website: www.gnpau.com, however the following lists the ingredients for ENDOR Arthritis Gel:

Aqua, Polyacrylamide, C13-14 Isoparaffin, Laureth – 7, Triticum Vulgare, Wheat Germ Oil, Glycerin, Sodium Citrate, Menthol, Dimethicone, Eucalyptus Globulus, Panthenol, Emu Oil, Phenoxyethanol, Benzoic acid, Dehydroacetic acid.

 

For any other questions you might have about ENDOR Arthritis Gel, please contact us: info@gnpau.com .

 

Advertisements

How do steroids work?

Steroids are hormones that are made by the body and they play an important role in our development. There are 5 types of steroids; glucocorticoids, mineralocorticoids, androgens, estrogens and progestogens. These hormones are important in the proper functioning of metabolism, immune system, salt and water balance, sexual organ development and the ability to recover from injury and withstand illness.

Natural steroids are produced by the adrenal glands. The steroids found in topical creams, ointments, injections and oral products are synthesized by the pharmaceutical companies and are called corticosteroids. They mimic the effects of the natural steroids. It is very important to bear in mind, that these externally introduced hormones will work against the naturally produced hormones and there is a conflict between the effects of two sources of the hormone.

Steroids work by affecting the body at the molecular level and they have a profound influence on the production of various proteins, i.e. they either increase production of certain proteins and reduce or stop production of other proteins and at some level, increase or stop cell replication. This is essentially how steroidal products work when used either as topical creams, ointments, cortisone injection or oral pills and capsules.

In the case of inflammatory conditions, steroidal products reduce or stop proliferation of immune cells. The immune system responds to invading pathogens and other threats, by rapidly multiplying various immune cells to deal with the risk to the body. Therefore, the inhibiting ability of the steroids is responsible for the reduction in immune response and this is why steroidal creams and ointments have been very popular with doctors who prescribe them for anything from an eczema rash to minor scrapes and skin inflammation, due to just about anything.

When steroidal products are used over a long period of time, in order for the body to resume to a normal immune response and protect the patients’ body from external threats, it will begin developing other means of promoting immune response and this is why after some time, the patient develops resistance to the steroids effect. Unfortunately, steroidal inhibition of protein production and cellular proliferation is not specific to the immune system and over time the body will use other means to overcome this steroidal inhibition and a new balance develops between the body’s natural steroidal hormonal levels and the externally introduced steroidal levels.

As the effectiveness of the steroidal products begins to decline, the temptation is to increase dosage and for a time, this will provide a remedy to the localised inflammation, but in many instances, those using the product have a more systemic condition and the continual use of steroidal products will ultimately lead to lack of effectiveness. At this point, if the patient stops using the steroidal product, the balance that the body has reached with the externally provided steroid product comes to an abrupt end and the patient will experience a “steroid withdrawal” and this in itself can be very stressful to the patient.

Happy Baby.jpeg

Today the number of babies and children with eczema and similar dermatological condition is on the rise and current estimates are as high as 25% of babies and children. This is a staggering increase in the diagnosis of new patients. As I mentioned earlier, using steroidal products inhibits the production of various proteins and cell proliferation. So babies and children with developing and evolving immune systems, that are put on steroid products for the treatment of their dermatological conditions, will ultimately have a deleterious effect on their immune system and their development and might influence their health and well being as adults.

 

Treat Autoimmune Dermatitis: Psoriasis, Eczema and Rosacea, from inside out

Autoimmunity is when the immune system is activated against the body and the resulting damage is manifested in different ways, however in the case of Eczema, Psoriasis and Rosacea, this is manifested by a rash and lesions on the skin. It is essential to keep in mind that autoimmunity is a problem with the immune system and the immune system covers all of the body, so even though you get a rash in atopic dermatitis, the problem is with the whole immune system.

To treat autoimmunity effectively, it is important to treat the whole of the immune system. One must still treat the site of the lesion, not only to relieve the itch and the dry scaly skin, but also to prevent further damage that may be caused by scratching. This will prevent making matters worse by causing a skin infection. However, as many who suffer from these conditions know, you can treat an area with a topical cream only to find the rash appears in another place.

For this reason, we have developed ENDOR™ Dermatitis Care. These capsules contain a number of vitamins such as Vitamin A, Vitamin E and Vitamin C as well as omega 3 fatty acids for a healthier skin. More importantly, they contain the precursors to the ENDOR™ active compound. These capsules are coated so that they do not dissolve in the stomach therefore protecting the ingredients from being digested by the stomach acids and enzymes. These capsules cannot be cut or pierced in anyway, as this will expose the contents to the stomach acids.

8

Two capsules of ENDOR™ Dermatitis Care per day for an adult, over a period of time, will calm the overactive immune response back to normal levels and in-conjunction with ENDOR™ Cream, ENDOR™ 3.5 and also ENDOR™ Exfoliant, will help bring the overactive immune response back to normal levels, without shutting the immune system down and exposing the patient to infection and other side effects.

ENDOR™ 3.5 and ENDOR™ Exfoliant are very effective in treating the affected lesions and locally reduce the overactive immune response. ENDOR™ Cream is then used for maintenance, however, in order to manage the overactive immune response in the body and to reduce chances of flare-ups, use ENDOR™ Dermatitis Care capsules for long-term management of your autoimmune skin condition: Psoriasis,Eczema, Atopic Dermatitis and Rosacea and to enjoy naturally healthier looking skin.

ENDOR™ Arthritis Gel

Differences between Clinical Trial of Drugs and Complementary Medicine

When developing new pharmaceutical products, there are many stages that the development process includes. Once it has reached human studies, which suggests that all previous steps have been rigorously accomplished successfully, then it is essential to demonstrate that the product is safe to use in humans.  This is called Phase I. This refers to Safety studies, which is paramount in the progress of the study to the next level.  Once the safety studies are completed, then it moves on to the next step.

Phase II refers to efficacy studies, where the product is used on patients suffering from the condition and the effectiveness of the product is evaluated. At this stage it is important that your product is effective in the treatment of the condition. Unfortunately nothing is straightforward. You will not have patients either being treated successfully or not. There is also a grey area where patients will feel better, but are not fully treated. There is a very complicated formula in working out how good your product is performing and what is acceptable, in order to take the product to the next level of clinical trials. At this stage, it is also very important to determine the side effect verses the treatment of the product. If the product has low side effects and high efficacy, then this would be ideal and ready to move on to the next phase.

Phase III clinical trial is when a larger number of people are involved, in order to demonstrate more convincingly the effectiveness of the product in the treatment of the condition.

There is also Phase IV clinical studies. This is usually after a product has been launched and is already available for sale. This is generally to demonstrate a longer-term use of the product, as well as getting people in different countries to demonstrate the effectiveness of the product in their country and also believe in the product.

Then there are the natural products or products that are considered to be complementary medicines. These products mainly contain herbal and vitamins and are generally considered to be safe to use. Complementary products can have a positive effect in the well being of the patients and can be positive in the treatment of various conditions. Usually, because the complementary products are low risk, they are usually available on the market and any studies carried out are going to be Phase IV studies (post marketing).

The results of these studies are then published in peer reviewed scientific journals. The purpose of peer review is that other people, who are experts in that area of science or medicine, will review the study and critique the findings and will allow its publication only after the data and findings pass a rigid criteria. Once published, the findings are available to the scientific, medical community worldwide. This is an effective method of communicating with the medical community of new products for the treatment of various conditions.  

We have developed a number of products, which are naturally sourced and have no risk associated with them. However, ENDOR™ products contain the precursors to an active compound, which the immune cells can make. We have developed products, which will present these precursors to the immune cells to be converted into the active compound. This active compound in turn signals the overactive autoimmune response to return to normal levels. By calming the autoimmune response, this will allow the natural healing processes to take over and for the body to return to healthy condition.

Call for volunteers for a clinical trial.

ENDOR™ products are a safe treatment for a number of chronic conditions. The reason we are conducting a clinical trial is to demonstrate the efficacy of ENDOR™ Cream for the treatment of Eczema, under a clinical trial setting (double blind, placebo controlled). Once the clinical trial is completed, we intend to publish our data in a peer reviewed scientific journal, to bring to the attention of the medical profession the availability of a safe alternative to current remedies for the treatment of Eczema. We are passionate about our work and the fact that our products are safe and effective for the treatment of Eczema, especially in an era where more children are being diagnosed with the condition. It is of the highest importance to ensure that they are being used for the treatment of this condition and not other products that have side effects and which dampen the immune system, particularly in babies and children.

It is our intention to follow this study with similar studies to demonstrate the effectiveness of our products for the treatment of Psoriasis, Rosacea and other autoimmune conditions.

What is Autoimmunity and why is it so difficult to find a cure?

In order to understand how autoimmunity comes about it is very important to have the basics of how the immune system works. The immune system is a very sophisticated defence mechanism. The immune system is composed of several interacting and related processes, which defend our body from invading bacteria, viruses and pathogens (antigens).

There are several types of immune defence mechanisms:

  • Innate immunity
  • Passive Immunity
  • Acquired Immunity

Innate Immunity

Innate immunity refers to a non-specific immune response and is usually the first line of defence. These involve skin barrier, tears and mucosal secretion, to prevent bacterial infection getting through and causing a problem. The innate humoral immunity includes various immune mediators such as, interferons and cytokines, as well as the blood’s complement system. These mediators play a very important role in defending our body against invading pathogens. For example Tumour Necrosis Factor – Alpha (TNF-a) is part of the immune defence and surveillance. This is a powerful molecule and as its name suggests, kills tumour cells. TNF-a has been shown to play a role in the onset of autoimmune conditions such as Psoriasis, Eczema, and Rheumatoid Arthritis. Biologics, which are antibodies designed to neutralise the TNF-a have been shown to be effective in the treatment of severe cases of Psoriasis, Eczema and Rheumatoid Arthritis, however by removing this important immune mediator, we are taking away an important arsenal from our defence mechanism, leaving us open to potential infections etc.

Cytokines play a very important role in the body’s defence and there are more of them being discovered every day and some of them have been shown to play a role in the development of the symptoms of the autoimmune condition. Once again, biologics are being developed to counter these specific cytokines, to reduce the symptoms of the autoimmune condition and once again by removing these cytokines the body is left open to certain infections etc.

Passive Immunity

This refers to the immunity in the form of antibodies, which have been passed from mother to child and play an important role in the early life of an infant. The passive immunity is not a long lasting immunity and these antibodies begin to disappear around 6-12 months of the child’s life. The other form of passive immunity is when antiserum is injected in an attempt to remove certain toxins and antigens. This form of immunity is short term and in some instances, over time and over use of these antiserum will lead to the body recognising these antibodies as foreign and reacting against them. Furthermore, over time, they tend to become less effective, as is the case with many biologics used to treat autoimmune conditions. This may be due to the person’s own immune system recognising these antibodies and rejecting them. 

Acquired Immunity

Acquired immunity is when the immune system is finely tuned to respond to specific antigens / pathogens and invading bacteria / viruses. This immunity improves with increased exposure to the antigens and your immune response becomes specific to the invading pathogens and antigens. This is also the way vaccination works. When a weak form of a pathogen or antigen is presented to the body, the body develops a response to the antigen and when in future it encounters it again, it is already capable of developing a specific antibody response and defeating the pathogen.

Autoimmunity conditions.jpgAutoimmunity

Autoimmunity refers to a condition where the immune system of the person suffering from autoimmunity tends to attack the person’s own body. How autoimmunity comes about is a complex process, however, in autoimmune conditions, the immune system sees the person’s own molecules and proteins as antigens and once the immune system has been activated, for example the person has an infection of some sort, then the immune response remains activated, even though the foreign invading infection has been destroyed and is no longer a threat. This is because the activated immune system remains active, as it continues to see the self-molecules as antigens.

In the early onset of autoimmunity, this recognition of self molecules is not strong and the condition presents itself as mild, but over time, due to continued activation of the immune system by external pathogens and infections, ultimately will lead to increased specificity of the immune response to the self molecules and over time the mild autoimmune condition will progress to moderate and ultimately to severe and it may even become life threatening.

So why is it so difficult to find a cure to autoimmunity?

The list of autoimmune conditions is rather long, but the following list gives an idea of autoimmune conditions: Eczema, Psoriasis, Rosacea, Lupus, Psoriatic Arthritis, Rheumatoid Arthritis, Multiple Sclerosis and the list goes on.

Although some immune mediators seem to play a central role in the symptoms of the autoimmune condition; for example TNF-a plays an important role in the symptoms of Psoriasis, Eczema and Rheumatoid Arthritis. The use of biologics in neutralising TNF-a seems to abate these conditions and bring them under control; however, biologics are not a cure and if the treatment is stopped the autoimmune conditions seem to return more severe than before. Furthermore, when a person is being treated with these biologics, in the long term they seem to lose efficacy and also leave the person open to side effects and severe infections. There are other drugs that dampen the immune response and are used in the treatment of autoimmune conditions, but invariably all of them have side effects.

Furthermore, at present there is uncertainty aboutwhich molecules play what role in any particular autoimmune condition, which makes developing effective products in treating and potentially curing autoimmunity very difficult. Most pharmaceutical companies are concentrating on reducing the symptoms, even though the long-term use of some of the current drugs leads to complications at a later time in life.

GNP-Australia

How does ENDOR work in treating autoimmunity?

ENDOR products are based on the discovery of an immune molecule, which signals the activated immune response back to normal levels. For the purposes of this article, let’s call this compound ENDOR active. GNP Australia, an Australian Pharmaceutical company has developed products; creams, gels and oral capsules, that contain the precursors to ENDOR active compound. These precursors, when presented to the immune system, are converted into ENDOR active, which in turn can turn the activated immune response back to normal levels. This does not shut the immune system down, as is the case with steroidal products, but returns it to normal levels. This is clearly demonstrated by the fact that if a person who is very sensitive to insect bits is bitten, by applying the ENDOR cream to the affected area, the immune response is retuned to normal levels and the resulting blister is not formed.

ENDOR active does not interfere with the normal immune mediators and does not shut the immune system down, however by signalling the activated immune response back to normal levels, the overactive immune response, which is responsible for the development of symptoms of the autoimmune conditions, will abate and the normal natural healing process can take over.

Screenshot 2017-07-10 17.20.15

ENDOR active is produced by the person’s own immune cells. Therefore when the basic ingredients (precursors) are presented to the person’s own immune cells, it will in effect kick-start the immune cells to convert the precursors into the active compound. It is therefore very important that the person’s own immune system is function and is not being dampened or shut down by immune suppressing drugs.

ENODR1The precursors to ENDOR active are natural ingredients and it is anticipated that over time the body will begin to source these ingredients independently and will be able to produce the ENDOR active to calm the overactive immune response and manage the autoimmunity. Furthermore, because the immune system is not being suppressed, the person’s immune system, remains available, to protect the body from bacterial and viral infections and also continue to have immune surveillance.

Screenshot 2017-07-10 17.16.57

It is anticipated that the long-term use of ENDOR products will lead to reduced flare-ups and reduced severity of the flare-ups. We have observed that when ENDOR cream has been used on young children and babies, for the treatment of Eczema, over a relatively short period of time, the child has grown out of the condition and is able to live a normal life.

ENDOR products offer an alternative, safe treatment for a number of autoimmune conditions. To date GNP Australia have developed products for the treatment of Eczema, Psoriasis, Rosacea, Atopic Dermatitis and most recently ENDOR Arthritis Gel to manage the pain in Arthritis.