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What is Autoimmunity and why is it so difficult to find a cure?

In order to understand how autoimmunity comes about it is very important to have the basics of how the immune system works. The immune system is a very sophisticated defence mechanism. The immune system is composed of several interacting and related processes, which defend our body from invading bacteria, viruses and pathogens (antigens).

There are several types of immune defence mechanisms:

  • Innate immunity
  • Passive Immunity
  • Acquired Immunity

Innate Immunity

Innate immunity refers to a non-specific immune response and is usually the first line of defence. These involve skin barrier, tears and mucosal secretion, to prevent bacterial infection getting through and causing a problem. The innate humoral immunity includes various immune mediators such as, interferons and cytokines, as well as the blood’s complement system. These mediators play a very important role in defending our body against invading pathogens. For example Tumour Necrosis Factor – Alpha (TNF-a) is part of the immune defence and surveillance. This is a powerful molecule and as its name suggests, kills tumour cells. TNF-a has been shown to play a role in the onset of autoimmune conditions such as Psoriasis, Eczema, and Rheumatoid Arthritis. Biologics, which are antibodies designed to neutralise the TNF-a have been shown to be effective in the treatment of severe cases of Psoriasis, Eczema and Rheumatoid Arthritis, however by removing this important immune mediator, we are taking away an important arsenal from our defence mechanism, leaving us open to potential infections etc.

Cytokines play a very important role in the body’s defence and there are more of them being discovered every day and some of them have been shown to play a role in the development of the symptoms of the autoimmune condition. Once again, biologics are being developed to counter these specific cytokines, to reduce the symptoms of the autoimmune condition and once again by removing these cytokines the body is left open to certain infections etc.

Passive Immunity

This refers to the immunity in the form of antibodies, which have been passed from mother to child and play an important role in the early life of an infant. The passive immunity is not a long lasting immunity and these antibodies begin to disappear around 6-12 months of the child’s life. The other form of passive immunity is when antiserum is injected in an attempt to remove certain toxins and antigens. This form of immunity is short term and in some instances, over time and over use of these antiserum will lead to the body recognising these antibodies as foreign and reacting against them. Furthermore, over time, they tend to become less effective, as is the case with many biologics used to treat autoimmune conditions. This may be due to the person’s own immune system recognising these antibodies and rejecting them. 

Acquired Immunity

Acquired immunity is when the immune system is finely tuned to respond to specific antigens / pathogens and invading bacteria / viruses. This immunity improves with increased exposure to the antigens and your immune response becomes specific to the invading pathogens and antigens. This is also the way vaccination works. When a weak form of a pathogen or antigen is presented to the body, the body develops a response to the antigen and when in future it encounters it again, it is already capable of developing a specific antibody response and defeating the pathogen.

Autoimmunity conditions.jpgAutoimmunity

Autoimmunity refers to a condition where the immune system of the person suffering from autoimmunity tends to attack the person’s own body. How autoimmunity comes about is a complex process, however, in autoimmune conditions, the immune system sees the person’s own molecules and proteins as antigens and once the immune system has been activated, for example the person has an infection of some sort, then the immune response remains activated, even though the foreign invading infection has been destroyed and is no longer a threat. This is because the activated immune system remains active, as it continues to see the self-molecules as antigens.

In the early onset of autoimmunity, this recognition of self molecules is not strong and the condition presents itself as mild, but over time, due to continued activation of the immune system by external pathogens and infections, ultimately will lead to increased specificity of the immune response to the self molecules and over time the mild autoimmune condition will progress to moderate and ultimately to severe and it may even become life threatening.

So why is it so difficult to find a cure to autoimmunity?

The list of autoimmune conditions is rather long, but the following list gives an idea of autoimmune conditions: Eczema, Psoriasis, Rosacea, Lupus, Psoriatic Arthritis, Rheumatoid Arthritis, Multiple Sclerosis and the list goes on.

Although some immune mediators seem to play a central role in the symptoms of the autoimmune condition; for example TNF-a plays an important role in the symptoms of Psoriasis, Eczema and Rheumatoid Arthritis. The use of biologics in neutralising TNF-a seems to abate these conditions and bring them under control; however, biologics are not a cure and if the treatment is stopped the autoimmune conditions seem to return more severe than before. Furthermore, when a person is being treated with these biologics, in the long term they seem to lose efficacy and also leave the person open to side effects and severe infections. There are other drugs that dampen the immune response and are used in the treatment of autoimmune conditions, but invariably all of them have side effects.

Furthermore, at present there is uncertainty aboutwhich molecules play what role in any particular autoimmune condition, which makes developing effective products in treating and potentially curing autoimmunity very difficult. Most pharmaceutical companies are concentrating on reducing the symptoms, even though the long-term use of some of the current drugs leads to complications at a later time in life.

GNP-Australia

How does ENDOR work in treating autoimmunity?

ENDOR products are based on the discovery of an immune molecule, which signals the activated immune response back to normal levels. For the purposes of this article, let’s call this compound ENDOR active. GNP Australia, an Australian Pharmaceutical company has developed products; creams, gels and oral capsules, that contain the precursors to ENDOR active compound. These precursors, when presented to the immune system, are converted into ENDOR active, which in turn can turn the activated immune response back to normal levels. This does not shut the immune system down, as is the case with steroidal products, but returns it to normal levels. This is clearly demonstrated by the fact that if a person who is very sensitive to insect bits is bitten, by applying the ENDOR cream to the affected area, the immune response is retuned to normal levels and the resulting blister is not formed.

ENDOR active does not interfere with the normal immune mediators and does not shut the immune system down, however by signalling the activated immune response back to normal levels, the overactive immune response, which is responsible for the development of symptoms of the autoimmune conditions, will abate and the normal natural healing process can take over.

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ENDOR active is produced by the person’s own immune cells. Therefore when the basic ingredients (precursors) are presented to the person’s own immune cells, it will in effect kick-start the immune cells to convert the precursors into the active compound. It is therefore very important that the person’s own immune system is function and is not being dampened or shut down by immune suppressing drugs.

ENODR1The precursors to ENDOR active are natural ingredients and it is anticipated that over time the body will begin to source these ingredients independently and will be able to produce the ENDOR active to calm the overactive immune response and manage the autoimmunity. Furthermore, because the immune system is not being suppressed, the person’s immune system, remains available, to protect the body from bacterial and viral infections and also continue to have immune surveillance.

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It is anticipated that the long-term use of ENDOR products will lead to reduced flare-ups and reduced severity of the flare-ups. We have observed that when ENDOR cream has been used on young children and babies, for the treatment of Eczema, over a relatively short period of time, the child has grown out of the condition and is able to live a normal life.

ENDOR products offer an alternative, safe treatment for a number of autoimmune conditions. To date GNP Australia have developed products for the treatment of Eczema, Psoriasis, Rosacea, Atopic Dermatitis and most recently ENDOR Arthritis Gel to manage the pain in Arthritis.

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Bought and paid for by the Pharmaceutical Industry

We have recently developed and launched a product to treat Arthritis. Our products are naturally sourced and do not contain drugs. They contain the precursors (basic ingredients) to a compound produced by the immune cells, that the person’s own immune cells can convert into the active compound and signal the overactive immune response back to normal levels.

Our products; ENDOR™ products, do not contain any steroids, biologics, antibiotics or anything else that could be taken as drugs. I have worked very hard to make sure that they are natural and therefore they come under the banner of complementary medicine. There are no side effects associated with them. In the case of our latest product: ENDOR Arthritis Gel, it does not contain any analgesics and unlike some other products currently marketed, it does not cause any burning sensation. Also, it does not have a strong smell; it has a mild menthol smell. I have been seeing Rheumatologists to give them free samples, so that they can offer them to their patients and for them to give feedback with respect to the patient’s preferences. This is the normal process of introducing doctors and specialists to new products for various treatments. Most of the time, the doctors use the free samples for their patients to get an idea of how good the product is for their patients and if they are happy with them. If they are happy with the feedback, they will then recommend / prescribe them to their patients.

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I have just heard back from one such Rheumatologist. It took a good few weeks to make an appointment to see him and after waiting 10 weeks to make sure he had had the opportunity to give out the samples and then get feedback, I contacted him. He wrote me an email saying that after I left him, he decided that he would not recommend complementary products to his patients. I know as a matter of fact that most of the pharmaceutical products they prescribe, have side effects and some of the side effects can be quite serious, although they say only a small number of people might get the so called side effects; we all hope that would not be us.

I also know for a fact that these drugs are subsidised by the government and they are costing us, the taxpayers, an absolute fortune and many patients claim that they stop working for them after a while.

So I ask myself, why would a Rheumatologist, who treats people suffering from painful joints and other similar conditions decide that he would not recommend complementary medicines in preference to big pharmaceutical company drugs. The fact remains that the Big Pharmaceutical drugs have side effects and some of these side effects can be quite serious.

The mind-set, which has been promoted by the pharmaceutical industry, is that ‘unless it comes out of some pharmaceutical company’s production line or is backed by them, it is probably not worth considering’. This is what I consider to be lack of duty of care to the patients and their welfare.

Heart-ache (attack) that comes with pain relief

Pain relief is one of the most important areas in the pharmaceutical industry and drug development. Unfortunately, most oral painkillers have been associated with ulcers and stomach bleeding. The other thing that has surfaced is the effect of painkillers on our heart and the increase in heart attacks. I recently read a paper in the British Medical Journal, reporting that the use of painkillers, even in a small amount, increases the risk of heart attack.

The sad part is that the people who need to take these painkillers are usually people suffering from painful ailments and really could do without yet another ailment added to their already bothersome health conditions.

I personally suffer from Arthritis and I am sure many people who suffer from arthritis attest to the fact, that during the winter months, your arthritis can make walking painful and especially at night, rather than getting a good nights sleep, you suffer from joint pain; counting hours.

I used to wake up in the morning feeling my knees locked and it took a while before I started getting some mobility, resembling a human being rather than our evolutionary ancestors, trying to support myself with my hand.

I went to see a rheumatologist in late 1990’s and was prescribed a course of Vioxx, which at the time was being touted as the miracle drug for arthritis. I started taking it and after only 3 days I was covered in spots. I called my rheumatologist and told him what had happened to me. He said that it could not be Vioxx and left it at that. Three days later I found out that Vioxx was being withdrawn from the market place because it had increased the risk of heart attack many fold and anyone who had taken it, even for a few days, was at risk of increased heart problems.

Vioxx was an oral product but even topical products for arthritis, that contain painkillers, are said to have a negative effect on your heart, particularly if you need to use them on a regular basis. This brings me to why I started this blog. I have developed products that are based on a compound produced by our own immune system, which calms the overactive immune response (Autoimmunity).

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I have called these products: ENDOR™ Cream, ENDOR™ 3.5, ENDOR™ Dermatitis care and ENDOR™ Arthritis Gel. These products contain naturally sourced ingredients and nothing that has any side effects. So it makes me very proud to be able to tell everyone that as far as I know these are the only products that do not contain any drugs, such as steroids, corticosteroids, painkillers, antibiotics or biologics.

ENDOR™ Arthritis Gel helps reduce the joint inflammation, lubricate the joints for ease of movement and when it’s used over a period of time, you will need to use it less frequently for your pain management.

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I would like to add a comment made by a lady with hand arthritis. She said that it does not burn you with the heat that some products have and you can use it as a hand cream, because it does not stink like some products she had used previously.

Treatment options for the more severe cases of Psoriasis, Eczema and Atopic Dermatitis.

I recently went to see a very experienced and very well regarded dermatologist, to tell him about our products for the treatment of Psoriasis, Eczema and Rosacea. He very kindly told me that by the time patients get referred to them, they would have been prescribed a range of topical steroidal products and their condition is usually quite severe.

He went on to say that their condition would usually range from moderate to severe and the options would usually be oral corticosteroids, such as Dexamethasone or the next level drugs: Methotrexate and then Biologics.

Methotrexate is a drug that is generally used to treat cancer of breast, skin, head, neck and lungs. Methotrexate is usually given after other drugs have been tried and failed. You can see the long list of side effects for Methotrexate by doing a Google search.

Biologics are antibodies raised against proteins, usually and in the case of autoimmune skins conditions, which include Psoriasis, Eczema, Rosacea etc, certain proteins that are part of the immune response, such as TNF (Tumour Necrosis Factor) or interleukins (IL), which are immune mediators and are part of the immune response. These antibodies would react with and neutralize these proteins and the patients generally respond and get better. It should be noted, that after a while, your immune system gets used to them and the biologics stop working as well. You might be moved on to another biologic, but that has its own issues. The list of side effects associated with biologics are fairly minor things such as, flue like symptoms, minor infections, nausea, diarrhea etc., but then there are the rare side effects, that you are sure would not affect you, which include severe infection and cancer and even death; that scares the hell out of me.

endortubes4 tubeswithartg-austl

I mentioned all these side effects to my dermatologist colleague and he said that the benefit of these drugs outweighs the side effects, which are generally tolerated and acceptable. Here I am trying to tell a really experienced Dermatologist, that we have products that do not have side effects and work really well, but it is falling on deaf ears.

ENDOR™ products do not contain any ingredients that have any side effects and they do not contain any steroids, biologics, antibiotics or for that matter anything that would tantamount as a drug, but they are very effective for autoimmune dermal conditions; Psoriasis, Eczema, Rosacea. Our oral capsules; ENDOR™ dermatitis care works from inside out to support our topical products. We have also recently launched our arthritis gel; ENDOR™ Arthritis Gel, for psoriatic arthritis, which does not contain any painkillers, steroids etc. and is effective in reducing the pain associated with arthritis and helps with mobility and joint movement.

So as the old saying goes, you can take the horse to water but you cannot make it drink. I have put everything on the line to developing these products, because I believe patients should have access to products without side effects, rather than accepting the risk / benefit that is often calculated, based on certain criteria and maybe in a few years from now, we are told, oops, shame they caused more problems than good.

Why we should educate our doctors as to what to prescribe rather than leave it to the pharmaceutical industry.

In today’s information technology, most people are capable of doing a really decent job of researching just about anything. When a patient goes to see their doctor and they are prescribed a steroidal product, for what is at the time a mild case of Eczema, Psoriasis or Rosacea, their research tells them about the side effects and expected results and more importantly they should NOT be using their prescribed steroidal cream for a long period of time. Unfortunately, as many people know, as soon as they stop using the steroidal product, the condition gets worse, so they persist and before long they are using it to the point that the skin becomes reliant on the steroid and a higher concentration cream is required and if they decide to stop using it, their condition will get worse, but this time it is considerably worse than the original rash, that they went to see their doctor about.

ENDOR™ Cream and ENDOR™ 3.5 are primarily two very good moisturizing creams, that contain some ingredients in a special configuration, that will allow the patients own immune cells to use these basic ingredients and to convert them into a natural ant-inflammatory compound. I discovered this natural anti-inflammatory compound in children with an overactive immune response. This natural anti-inflammatory compound in-turn calms the overactive immune response and brings the immune response back to normal levels. This makes ENDOR™ Cream and ENDOR™ 3.5 ideal for use on conditions such as Eczema, Psoriasis and Rosacea and Atopic Dermatitis as well as other inflammatory skin conditions. Because ENDOR™ products contain naturally sourced ingredients and because they do not have any known side effects, they should be the first product that your GP prescribes, especially for children and elderly, rather than reaching for the first topical steroidal product or anything else that has side effects.

ENDOR Results 2

GP’s are too busy and are usually introduced to a new product by the pharmaceutical reps that come along with a prepared document and some freebies. They usually present a very well crafted study, performed by doctors sponsored by the pharmaceutical company, about how good a new product is, that this pharmaceutical company is trying to sell and by the way, the side effects, irrespective of how horrible they might be, only happens to a small number of people and that is within acceptable parameters.

I have been trying for the past 6 months to get approval from the Royal Australian College of General Practitioners to get approval to do a small study, showing the effectiveness of ENDOR™ 3.5 in treating Eczema. This has been an incredible journey. I was chatting with one of my friends, who works for one of the big pharmaceutical companies and I mentioned the difficulty that I am having and the queries that are being brought up. He said they don’t usually have these problems. They usually sail through this part.

So I am asking the people who have been using ENDOR™ products to help us and to spread the word to your G.P. I think it is our responsibility to tell our G.Ps about ENDOR™ and your first hand experience, rather than wait on the sidelines whilst yet another person goes through Steroid Withdrawal or especially a child who is treated with a product, that will have long term side effects.

Thank you and I look forward to your assistance in this regard.